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Zepbound: Decoding the Science

Zepbound (tirzepatide) is a dual-agonist that targets both GLP-1 and GIP pathways to curb appetite, slow gastric emptying, improve glucose control, and drive clinically meaningful weight loss when paired with lifestyle changes.

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· by Dr Ketikian
Zepbound: Decoding the Science

How Tirzepatide Works

  • Hypothalamus Activation: Tirzepatide targets the hypothalamus, the brain’s control center for appetite and metabolism. This activation helps regulate key physiological functions related to weight.
  • Reduced Food Cravings: It lowers food cravings and enhances satiety, effectively reducing overall intake.
  • Caloric Control: By influencing appetite and fullness, it supports better day-to-day caloric control.
  • Glucose Gains: Tirzepatide improves sugar metabolism and post-meal glucose handling.
  • Incretin Insights: It mimics incretin activity to aid insulin secretion and support healthier blood sugar levels.
  • GIP’s Role: The GIP component slows gastric emptying and prolongs satiety, helping you feel fuller for longer.
  • Comparative Advantage: Versus traditional single GLP-1 agonists, tirzepatide’s dual-action mechanism has shown greater weight loss and stronger glycemic effects in trials.

Final Thoughts

Zepbound (tirzepatide) works through a dual GLP-1/GIP pathway to reduce appetite, increase fullness, and improve glycemic control—making it a powerful option for medical weight management. For best results, pair therapy with nutrition, movement, sleep, and ongoing clinical follow-up.

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Disclaimer: The information provided on this website, including blog posts, is for general educational and informational purposes only and is not intended as medical advice. As a board-certified physician, I aim to share insights based on clinical experience and current medical knowledge. However, this content should not be used as a substitute for individualized medical care, diagnosis, or treatment. Always consult your own healthcare provider before making any changes to your health, medications, or lifestyle. marmean and its affiliates disclaim any liability for loss, injury, or damage resulting from reliance on the information presented here.

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