Serious Hypersensitivity Reactions
A serious hypersensitivity to the medication or any formulation component is one significant contraindication. Patients need to be aware of potential allergic reactions, including anaphylaxis. These reactions can be severe and require immediate medical attention.
Thyroid Considerations
Patients with a personal or family history of medullary thyroid carcinoma or those diagnosed with multiple endocrine neoplasia syndrome type 2 (MEN 2) should avoid GLP-1 weight loss injections. Animal studies have shown dose- and duration-dependent proliferative effects on thyroid C-cells. This same effect is not seen in primates, which may indicate rodent specificity. While C-cell tumors were observed in animal studies with GLP-1 agonists, the relevance to humans remains uncertain.
Pregnancy and Breastfeeding
Women who are pregnant or breastfeeding should avoid weight loss injections.
Gastrointestinal and Kidney Health: Dehydration
Individuals with a history of severe vomiting or diarrhea should be cautious. These medications slow gastric emptying and can worsen symptoms, leading to dehydration and potential kidney injury. During dehydration, co-administration of nephrotoxic medications can further increase risk. Those with preexisting kidney impairment require close monitoring.
Diabetes Management
For individuals with diabetes, the risk of early worsening of diabetic retinopathy can increase when intensive treatment is initiated, especially with long-standing poor glycemic control. Close monitoring and coordination with healthcare providers are essential.
Pancreatitis Risk
Patients with a prior history of pancreatitis may face increased risk when taking weight loss injections. Factors such as high triglycerides, gallstones, and alcohol use may contribute and should be evaluated.
Final Thoughts
Safety comes first. Understanding contraindications—hypersensitivity, specific thyroid histories, pregnancy/breastfeeding, significant GI or kidney issues, diabetes-related eye risk, and past pancreatitis—helps you and your clinician decide whether GLP-1 therapies are appropriate. With the right screening and follow-up, you can choose a path that supports your goals while protecting your health.
Disclaimer: The information provided on this website, including blog posts, is for general educational and informational purposes only and is not intended as medical advice. As a board-certified physician, I aim to share insights based on clinical experience and current medical knowledge. However, this content should not be used as a substitute for individualized medical care, diagnosis, or treatment. Always consult your own healthcare provider before making any changes to your health, medications, or lifestyle. marmean and its affiliates disclaim any liability for loss, injury, or damage resulting from reliance on the information presented here.