Understanding Weight Loss Injections: Important Considerations and Who Should Not Take Them

Serious Hypersensitivity Reactions

A serious hypersensitivity to the medication or any formulation component is one significant contraindication. Patients need to be aware of potential allergic reactions, including anaphylaxis. These reactions can be severe and require immediate medical attention.

Thyroid Considerations

Patients with a personal or family history of medullary thyroid carcinoma or those diagnosed with multiple endocrine neoplasia syndrome type 2 (MEN 2) should avoid GLP 1 weight loss injections. Animal studies have shown dose and treatment duration-dependent proliferative effects on thyroid C-cells. This same effect is not seen in primates which may indicate that it is rodent specific. While the development of thyroid C-cell tumors was noted during animal studies with GLP 1 agonists, the human relevance of these findings remains unknown.

Pregnancy and Breastfeeding

Women who are pregnant or breastfeeding should avoid weight loss injections.

Gastrointestinal and Kidney Health: Dehydration

Individuals who already have a history of severe vomiting or diarrhea should be cautious when considering weight loss injections. These medications can further exacerbate these symptoms because they slow stomach emptying. This can lead to dehydration and ultimately kidney injury. During episodes of dehydration, co-administration of medications known to cause kidney injury can further exacerbate the risk. Additionally, individuals with preexisting kidney impairment need to be monitored closely to prevent complications.

Diabetes Management

For individuals with diabetes, the risk of early worsening of diabetic retinopathy is increased when intensive treatment is initiated, especially in those with long-standing poor blood sugar control. Close monitoring and coordination with healthcare providers are essential to manage this risk effectively.

Pancreatitis Risk

Patients with a prior history of pancreatitis may face an increased risk when taking weight loss injections. Factors such as high triglycerides, gallstones, and alcohol use may contribute to the development of pancreatitis and need to be considered.

Conclusion

It’s my priority to ensure the safety and well-being of my patients. By understanding these contraindications and risks, individuals can make informed decisions about their weight loss options and work towards achieving their goals safely and effectively.