Are All Calories Created Equal? Not Exactly — and Here’s Why

Not all calories behave the same in your body. Learn how food quality, macronutrients, metabolism, and hormones play a role in how your body processes what you eat.

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December 25, 2024 · by Dr. Ketikian
Are All Calories Created Equal? Not Exactly — and Here’s Why

Introduction

“Calories in, calories out” is a phrase you'll hear often — especially in fitness and weight loss spaces. But while calorie quantity does matter, the story is far more nuanced. The type of food you eat affects your hormones, metabolism, cravings, and even how many calories you burn just by digesting it. In other words: not all calories are created equal.

What Is a Calorie, Really?

A calorie is simply a unit of energy. It tells us how much energy a food provides. But it doesn't tell us anything about the food's nutritional value, effect on metabolism, or how full it makes you feel.

How Does the Body Process Different Foods?

Protein, fat, and carbohydrates each have different effects on your body. Even if two foods have the same number of calories, they can be metabolized very differently.

  • Protein has a high thermic effect (you burn more calories digesting it) and is the most filling macronutrient.
  • Fat is calorie-dense but supports hormone production and satiety.
  • Carbs vary widely — simple carbs like sugar spike blood sugar quickly, while complex carbs provide fiber and stable energy.

Do 100 Calories from Soda and Salmon Act the Same?

Not at all. Consider 100 calories of soda versus 100 calories of grilled salmon:

  • Soda: Quickly absorbed, spikes blood sugar and insulin, no fiber or nutrients, leads to crash and hunger.
  • Salmon: High-quality protein and fat, promotes fullness, supports metabolism and hormone health.

Same calories — totally different impact.

What Is the Thermic Effect of Food?

This refers to the energy used to digest and absorb nutrients. Your body burns more calories digesting protein than it does digesting fat or carbs.

  • Protein: ~20–30% of calories burned during digestion
  • Carbs: ~5–10%
  • Fats: ~0–3%

This means 100 calories of protein might result in a net gain of only 70–80 usable calories, compared to nearly all 100 from fat.

What About Insulin and Blood Sugar?

Foods that spike insulin (especially refined carbs and sugar) promote fat storage and can lead to energy crashes, cravings, and overconsumption later. On the other hand, protein- and fiber-rich foods lead to stable blood sugar and longer-lasting energy.

Does Food Quality Matter?

Absolutely. Two meals can be equal in calories but vastly different in how they affect inflammation, gut health, mood, and satiety.

For example:

  • Processed snack bar: low fiber, high sugar, quick to digest, leaves you hungry
  • Hard-boiled eggs and veggies: nutrient-dense, satiating, low glycemic impact

What Role Do Hormones Play?

Food quality influences hormones like:

  • Ghrelin (hunger hormone)
  • Leptin (satiety hormone)
  • Insulin (blood sugar regulation)
  • Cortisol (stress and belly fat)

A balanced diet that includes enough protein, healthy fat, and fiber helps keep these hormones in check — which supports long-term weight regulation and metabolic health.

Are Processed Foods More Fattening?

Studies show that people tend to eat more when consuming ultra-processed foods — even when calories are controlled. These foods are engineered to override fullness signals and trigger cravings.

Whole, minimally processed foods, by contrast, promote natural fullness and help you eat less without trying.

Is Calorie Counting Still Useful?

It can be — but it’s just one piece of the puzzle. Calorie awareness is helpful, but food quality and macronutrient balance are often more important for long-term health and sustainable weight management.

What Should You Focus On Instead?

Rather than obsessing over numbers, focus on:

  • Eating enough protein and fiber
  • Choosing mostly whole, unprocessed foods
  • Limiting sugar and refined carbs
  • Watching portion sizes — especially with high-calorie, low-nutrient foods

Final Thoughts

Yes, calories matter. But what those calories are made of — and how they affect your body — matters just as much. By focusing on quality over quantity, you’ll naturally support your hunger cues, metabolism, and overall health.

So instead of asking “How many calories is this?”, try asking “What will this food do for my body?” That’s the question that leads to lasting results.

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